Can miRNA Indicate Risk of Illness after Continuous Exposure to M. tuberculosis?

نویسندگان

چکیده

The role of regulatory elements such as small ncRNAs and their mechanisms are poorly understood in infectious diseases. Tuberculosis is one the oldest diseases humans it still a challenge to prevent treat. Control infection, well its diagnosis, complex current treatments used linked several side effects. This study aimed identify possible biomarkers for tuberculosis by applying NGS techniques obtain global miRNA expression profiles from 22 blood samples infected patients with (n = 9), respective healthy physicians 6) external individuals controls 7). Samples were run through pipeline consisting differential expression, target genes, gene set enrichment miRNA–gene network analyses. We observed 153 altered miRNAs, among which only three DEmiRNAs (hsa-let-7g-5p, hsa-miR-486-3p hsa-miR-4732-5p) found between investigated physicians. These suggested play an important granuloma regulation immune physiopathology. Our results indicate that miRNAs may be involved modulation regulating cells system. findings encourage application potential tuberculosis.

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ژورنال

عنوان ژورنال: International Journal of Molecular Sciences

سال: 2021

ISSN: ['1661-6596', '1422-0067']

DOI: https://doi.org/10.3390/ijms22073674